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Researchers are still investigating and developing technologies to maximize these materials potential and mitigate their drawbacks ( 4.1 Beneficial/advantageous features correlated with chitosan (CH) Considering a chemical, structural, and functional perspective, chitosan (CH) and its derivatives provide several advantageous properties for therapeutic application (Wang et al., 2020b)

For example, selective knock out of -Klotho in regions of the central nervous system abolishes induction of adipose tissue browning, while central infusion of FGF21 increased energy expenditure (289)

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